R112

Overview

R112 is a fast and reversible inhibitor of spleen tyrosine kinase ( Syk ) kinase. R112 inhibits Syk kinase activity with an IC 50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Syk

Product Information

• Catalog No.: HY-16420
• CAS No.: 575474-82-7
• Molecular Formula: C16H13FN4O2
• Molecular Weight: 312.30
• Purity: 98.90%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.75 mg/mL (8.81 mM); Clear solution
• Availability: In-stock

Source

Original product source