E197

Overview

E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption ( IC 50 =3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC 50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > DOCK

Product Information

• Catalog No.: HY-164587
• CAS No.: 2378515-04-7
• Molecular Formula: C19H21ClN2O3S
• Molecular Weight: 392.90
• Purity: 99.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source