FAPI-mFS

Overview

FAPI-mFS is a selective fibroblast activation protein ( FAP ) inhibitor with an IC 50 of 0.0014 μM against human FAP . Through its covalent binding property with FAP , FAPI-mFS enhances its uptake and retention time in cancer cells. When radiolabeled with 68 Ga, FAPI-mFS serves as a PET/CT imaging agent with superior tumor-to-background tissue contrast and lesion detection capability. When radiolabeled with 177 Lu or 225 Ac, FAPI-mFS induces tumor regression and inhibition in preclinical models. FAPI-mFS can be used in studies related to cancer and radionuclide-conjugated drugs (RDC).

Application

Products | Products > Peptides | Products > Disease Areas > Cancer | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Radionuclide-Drug Conjugates (RDCs) | Products > Signaling Pathways > FAP

Product Information

• Catalog No.: HY-164725
• CAS No.: 3023869-94-2
• Molecular Formula: C53H69F3N12O15S
• Molecular Weight: 1203.25
• Purity: 98.71%
• Storage: Sealed storage, away from moisture. Powder -80°C, 2 years , -20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (2.08 mM); Clear solution
• Availability: In-stock

Source

Original product source