(4S)-GLP-1 receptor agonist 14 is a potent and orally active GLP-1 receptor agonist with an EC 50 ≤ 20 nM. (4S)-GLP-1 receptor agonist 14 can be used for research on diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, nonalcoholic steatohepatitis (NASH), and other diseases associated with GLP-1 receptor .
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