SBI-810

Overview

SBI-810 is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1 -mediated Gq activation. SBI-810 inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase ( ERK ) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 is applicable to research related to multiple pain disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Disease Areas > Acute Pain | Products > Disease Areas > Postoperative Pain | Products > Disease Areas > Mechanical Allodymia | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Neurotensin Receptor | Products > Signaling Pathways > Arrestin | Products > Signaling Pathways > iGluR

Product Information

• Catalog No.: HY-164795
• CAS No.: 1849603-79-7
• Molecular Formula: C27H34N4O2
• Molecular Weight: 446.58
• Purity: 98.25%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (2.24 mM); Clear solution
• Availability: In-stock

Source

Original product source