TMX-2138

Overview

TMX-2138 is a CDKs PROTAC degrader, with IC 50 s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer . (Pink: CDK ligand ( HY-151071 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W008352 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-164906
• CAS No.: 2488892-07-3
• Molecular Formula: C40H43BrFN9O11S
• Molecular Weight: 956.79
• Purity: 98.99%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source