PZ-3022

Overview

PZ-3022 is an orally active allosteric agonist of pantothenate kinase ( PanK ) with an EC 50 of 5.3 nM against PanK3 . PZ-3022 antagonizes the inhibitory effect of C3-CoA. PZ-3022 increases CoA levels in cells and the liver, upregulates CoASH and C2-CoA, downregulates C3-CoA, and restores impaired TCA cycle and mitochondrial function. PZ-3022 can be used for the research of propionic acidemia and metabolic CoA deficiency.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PANK

Product Information

• Catalog No.: HY-164909
• CAS No.: 2170608-85-0
• Molecular Formula: C20H21N5O
• Molecular Weight: 347.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source