SCH-900875

Overview

SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors . SCH-900875 binds to CXCR3 , blocking the binding of ligands CXCL9 , CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > Arrestin

Product Information

• Catalog No.: HY-165428
• CAS No.: 907206-98-8
• Molecular Formula: C28H37ClN8O2
• Molecular Weight: 553.10
• Purity: 98.16%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.52 mM); Clear solution
• Availability: In-stock

Source

Original product source