AVP-13358

Overview

AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E ( IgE )-mediated immune responses, with IC 50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4 , IL-5 , and IL-13 . It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-165484
• CAS No.: 459805-03-9
• Molecular Formula: C30H29N5O2
• Molecular Weight: 491.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source