Butein

Overview

Butein is a cAMP-specific PDE inhibitor with an IC 50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC 50 s of 16 and 65 μM for EGFR and p60 c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

Application

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Product Information

• Catalog No.: HY-16558
• CAS No.: 487-52-5
• Molecular Formula: C15H12O5
• Molecular Weight: 272.25
• Purity: 99.64%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution
• Availability: In-stock

Source

Original product source