BM-573

Overview

BM-573 is an orally active dual thromboxane A₂ ( TXA₂ ) modulator with an IC 50 of 1.3 nM. BM-573 possesses both thromboxane synthase ( TxAS ) inhibition and thromboxane receptor ( TP ) antagonistic effects. BM-573 can completely inhibit platelet aggregation induced by Arachidonic acid ( HY-109590 ) or U-46619 (TXA₂ analogues). BM-573 completely blocks the generation of TXB₂ (the stable metabolite of TXA₂) in human platelets and does not inhibit cyclooxygenase (COX-1/COX-2), thus avoiding interference with other prostaglandin synthesis. BM-573 has an inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle ( ED₅₀ = 4.2 μM), but has no effect on contractions caused by PGE₂, PGF₂α, or PGI₂. BM-573 can be used in the study of atherosclerosis, myocardial infarction, pulmonary hypertension and shock.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-165587
• CAS No.: 284464-83-1
• Molecular Formula: C18H22N4O5S
• Molecular Weight: 406.46
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source