MCB-22-174

Overview

MCB-22-174 is a deuterated Piezo1 agonist, with an EC 50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca 2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Others | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > Piezo Channel | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-165607S
• CAS No.: 3058199-58-6
• Molecular Formula: C16H14DCl2N5OS2
• Molecular Weight: 429.37
• Purity: 99.78%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source