(S)-LY-41, R-enantiomer of LY-41 ( HY-165624 ), is 2-Sminotetralin ( HY-W022362 ) derivative and 8-OH-DPAT ( HY-112061 ) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease , such as depression and anxiety.
Products | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Drug Isomer | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > 5-HT Receptor
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