SIRT6-IN-6

Overview

SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC 50 of 4.93 μM and a K i of ~10 μM. SIRT6-IN-6 shows selectivity against other members of the HDAC family ( SIRT1-3 and HDAC1-11 ). SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1 , thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > GLUT

Product Information

• Catalog No.: HY-16605
• CAS No.: 23491-48-7
• Molecular Formula: C11H16N4O2
• Molecular Weight: 236.28
• Purity: 98.59%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source