ML314

Overview

ML314 is a potent, BBB-penetrant and β-arrestin biased molecule agonist of NTR1 ( EC 50 = 1.9 μM). ML314 shows good selectivity against NTR2 and GPR35 , but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > GPR35 | Products > Signaling Pathways > Neurotensin Receptor

Product Information

• Catalog No.: HY-16639
• CAS No.: 1448895-09-7
• Molecular Formula: C24H28N4O3
• Molecular Weight: 420.50
• Purity: 99.52%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.5 mg/mL (5.95 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source