(-)-Niguldipine hydrochloride

Overview

(-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 ( HY-108566 )-induced coronary artery contraction in guinea pig Langendorff hearts ( pID 50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes ( K i of 8.10), and lowers blood pressure in spontaneously hypertensive rats ( pED 30 of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.

Application

Products | Products > Disease Areas > Arrhythmias | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Hypertension | Products > Disease Areas > Angina | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-101390A
• CAS No.: 113145-70-3
• Molecular Formula: C36H40ClN3O6
• Molecular Weight: 646.17
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source