O-Desmethyl carvedilol-d 5

Overview

O-Desmethyl carvedilol-d 5 (Desmethylcarvedilol-d 5 ) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol ( HY-B0006 ). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C ( RyR2 R4496C ) mutation ( IC 50 = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol ( HY-B0468 ) in conscious rabbits ( ED 50 s = 32 and 5 μg/kg, respectively).

Application

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Product Information

• Catalog No.: HY-166478S
• CAS No.: 1794817-24-5
• Molecular Formula: C23H19D5N2O4
• Molecular Weight: 397.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source