VU 0240551

Overview

VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor ( IC 50 =560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca 2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Others | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-16689
• CAS No.: 893990-34-6
• Molecular Formula: C16H14N4OS2
• Molecular Weight: 342.44
• Purity: 99.70%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution
• Availability: In-stock

Source

Original product source