ICA-069673 (Standard) is the analytical standard of ICA-069673 ( HY-101396 ). This product is intended for research and analytical applications. ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca (2+) concentration in DSM cells.
Products | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Reference Standards
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