RTI-122

Overview

RTI-122 is a selective, blood-brain barrier-permeable GPR88 agonist ( cAMP EC 50 =11 nM), with EC 50 values of 11.5 nM and 155 nM for human and mouse GPR88 , respectively ([ 35 S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 significantly attenuates Binge -like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 exhibits metabolic stability in mice (T 1/2 =5.8 h) and can be used to investigate alcohol use disorder.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Behavioral Addiction | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GPR88

Product Information

• Catalog No.: HY-167856
• CAS No.: 3034664-39-3
• Molecular Formula: C29H34FN3O3
• Molecular Weight: 491.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source