ICA-121431

Overview

ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na v ) blocker, shows equipotent selectivity for human Na v 1.1 and Na v 1.3 subtypes with IC 50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na v 1.2 ( IC 50 =240 nM) and 1,000 fold selectivity against Na v 1.4, Na v 1.6, and the TTX-resistant human Na v 1.5 and Na v 1.8 channels ( IC 50 s >10 μM).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Sodium Channel

Product Information

• Catalog No.: HY-16787
• CAS No.: 313254-51-2
• Molecular Formula: C23H19N3O3S2
• Molecular Weight: 449.55
• Purity: 99.35%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution
• Availability: In-stock

Source

Original product source