ASP-8731

Overview

ASP-8731 is an orally active BACH1 inhibitor. ASP-8731 activates antioxidant, anti-inflammatory and globin gene pathways by relieving the inhibitory effect of BACH1 on NRF2 -mediated gene transcription. ASP-8731 significantly upregulates the expression of HMOX1 , FTH1 and various globins (such as HGB, HBG, HBA ), increases fetal hemoglobin ( HbF ) levels, and effectively induces F-cell production in hydroxyurea-unresponsive cells. Meanwhile, ASP-8731 reduces inflammatory responses and white blood cell counts by downregulating VCAM1 , ICAM-1 and the phosphorylation level of NF-κB (p65), and blocks heme-induced glutathione depletion and microcirculatory stasis. ASP-8731 holds potential for inhibiting sickle cell disease and related hematological disorders.

Application

Products | Products > Disease Areas > Sickle Cell Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Transmembrane Glycoprotein

Product Information

• Catalog No.: HY-167874
• CAS No.: 2488255-42-9
• Molecular Formula: C20H21N5O4
• Molecular Weight: 395.41
• Purity: 98.42%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (12.65 mM); Clear solution
• Availability: In-stock

Source

Original product source