Ono 3307 free base

Overview

Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner. Ono 3307 Free base is able to target trypsin (K i =48 nM), thrombin (K i =0.18 μM), plasma kallikrein (K i =0.29 μM), plasmin (K i =0.31 μM), pancreatic kallikrein (K i =3.6 μM), and chymotrypsin (K i =47 μM).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Kallikrein | Products > Signaling Pathways > Ser/Thr Protease | Products > Signaling Pathways > Thrombin

Product Information

• Catalog No.: HY-167924
• CAS No.: 76472-28-1
• Molecular Formula: C14H14N4O4S
• Molecular Weight: 334.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source