Cx43 HC-IN-1

Overview

Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels ( Cx43 HC ). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases.

Application

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Product Information

• Catalog No.: HY-167983
• CAS No.: 1840896-10-7
• Molecular Formula: C24H16ClNO3
• Molecular Weight: 401.84
• Purity: 99.61%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (12.44 mM); Suspended solution
• Availability: In-stock

Source

Original product source