PROTAC YAP degrader-1

Overview

PROTAC YAP degrader-1 is a VHL -recruiting PROTAC degrader ( DC 50 =8.2 μM) and antiproliferative agent that targets YAP . PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP . PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP / TEAD -mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma. (Pink: YAP ligand ( HY-168017 ); Blue: E3 ligase ligand; Black: linker ( HY-140480 )).

Application

Products | Products > Disease Areas > Melanoma | Products > Disease Areas > Hepatitis B Virus Related Hepatocellular Carcinoma | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > YAP

Product Information

• Catalog No.: HY-168016
• CAS No.: 3058483-58-9
• Molecular Formula: C56H62N6O9S
• Molecular Weight: 995.19
• Purity: 99.77%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source