PROTAC K-Ras Degrader-3

Overview

PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC 50 of ≤ 1 nM against SW620 KRAS G12D, and a GI 50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC). (Pink: K-RAS ligand ( HY-168056 ); Blue: Cereblon ligand ( HY-168055 ); Black: linker ( HY-168075 )).

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-168054
• CAS No.: 3043670-68-1
• Molecular Formula: C57H67F2N9O6
• Molecular Weight: 1012.20
• Purity: 99.75%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.47 mM); Clear solution
• Availability: In-stock

Source

Original product source