DD205-291

Overview

DD205-291 is a selective, orally active HPK1 PROTAC degrader with a DC 50 of 8.8 nM. By inducing complete degradation of HPK1 protein, DD205-291 simultaneously blocks both its kinase-dependent functions and non-kinase scaffold functions. DD205-291 inhibits the phosphorylation of SLP-76 with an EC 50 of 22.98 nM. DD205-291 induces the production of IL-2 and IFN-γ with EC 50 values of 34.68 nM and 32.6 nM, respectively. Combined with anti- PD1 in mouse models, DD205-291 exerts tumor-suppressive effects with favorable safety profiles. DD205-291 can be used in colon cancer-related research. (Pink: HPK1 ligand ( HY-168283 ); Blue: Cereblon ligand ( HY-W115490 ); Black: linker).

Application

Products | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > MAP4K | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-168282
• CAS No.: 3047066-15-6
• Molecular Formula: C38H38ClF3N10O3
• Molecular Weight: 775.22
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source