HLB-0532259

Overview

HLB-0532259 is a Aurora-A/N-Myc PROTAC degrader, with a DC 50 of 20.2 nM against Aurora-A in MCF-7 cells; its DC 50 values against N-Myc are 179 nM in SK-N-BE (2) cells and 229 nM in Kelly cells, respectively. HLB-0532259 induces apoptosis ( apoptosis ) in MYCN-amplified neuroblastoma cells and inhibits tumor growth in mouse xenograft models. HLB-0532259 can be used for the research of neuroblastoma. (Pink: Aurora A and N-Myc ligand ( HY-168440 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-W007957 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-168439
• CAS No.: 2566733-45-5
• Molecular Formula: C40H44N8O7
• Molecular Weight: 748.83
• Purity: 98.30%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (6.68 mM); Clear solution
• Availability: In-stock

Source

Original product source