PROTAC IRAK4 degrader-12

Overview

PROTAC IRAK4 degrader-12 is an orally active IRAK4 PROTAC degrader with a DC 50 of 4.87 nM in K562 IRAK4-HiBiT cells. PROTAC IRAK4 degrader-12 induces protein degradation of IRAK4 , IKZF1 and IKZF3 . It inhibits the proliferation of diffuse large B-cell lymphoma cells. It suppresses tumor growth in mouse xenograft models of lymphoma cells. PROTAC IRAK4 degrader-12 can be used for the research of B-cell lymphoma and diffuse large B-cell lymphoma. (Pink: IRAK4 ligand ( HY-168611 ); Blue: Cereblon ligand ( HY-W733885 ); Black: linker ( HY-75005 )).

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Diffuse Large B-cell Lymphoma | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > IKZF Family

Product Information

• Catalog No.: HY-168586
• CAS No.: 2919995-09-6
• Molecular Formula: C46H50ClF2N11O6
• Molecular Weight: 926.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source