MRT-6160

Overview

MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC 50 : 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc..

Application

Products | Products > Disease Areas > Arthritis | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Multiple Sclerosis | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > PROTAC | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Molecular Glues

Product Information

• Catalog No.: HY-168625
• CAS No.: 3050683-38-7
• Molecular Formula: C22H17ClN2O3
• Molecular Weight: 392.83
• Purity: 99.51%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.36 mM); Clear solution
• Availability: In-stock

Source

Original product source