Antibacterial agent 254 (Compound 2) is a dispersion sensor ( DspS ) activator that disperses Pseudomonas aeruginosa biofilms. Antibacterial agent 254 can dislodge 7-day P. aeruginosa biofilms at 50 μM. Antibacterial agent 254 also enhances the effects of Ciprofloxacin ( HY-B0356 ) against P. aeruginosa and increases the expression of matrix-degrading enzyme genes pelA, pslG and eddA.
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