SIAIS562055

Overview

SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a K d of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRAS G12C or KRAS G12D to SOS1, with the IC 50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand ( HY-168638 ); Blue: Cereblon ligand ( HY-W586108 ); Black: linker ( HY-W009145 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SOS1 | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-168637
• CAS No.: 3062106-15-1
• Molecular Formula: C49H62F3N7O5S
• Molecular Weight: 918.12
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source