Resolvin D2 n-3 DPA is a specialized proresolving mediator ( SPM ). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α . Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 ( CCL2 ) in a mouse model of inflammation induced by zinc oxide.
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