LTD4 antagonist 2 (compound 6) is a leukotriene D4 ( LTD4 ) antagonist with an IC 50 of 2.8 μM against cysteinyl leukotriene 1 receptor ( CysLT1R ). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 ( GPBAR1 ) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.
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