RD-23

Overview

RD-23 is an orally active and selective RET PROTAC degrader, with DC 50 values of 5.6 nM and 11.7 nM against RET WT and RET G810C mutants, respectively. RD-23 inhibits purified RET kinase activity with an IC 50 of 0.371 nM. RD-23 suppresses the activation of downstream Shc signaling and induces apoptosis . RD-23 can be used for the research of RET-related cancers. (Pink: RET ligand ( HY-168868 ); Blue: Cereblon ligand ( HY-43722 ); Black: linker ( HY-W010642 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > RET | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-168867
• CAS No.: 3053537-06-4
• Molecular Formula: C52H56N12O4
• Molecular Weight: 913.08
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source