JNJ-54082730

Overview

JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase ( PDE ) that inhibits PDE2A , PDE3B , and PDE10A2 with IC 50 s of 0.95 nM, 6.17 μM (pIC 50 =5.21) and 87.1 nM (pIC 50 =7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor , enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > iGluR

Product Information

• Catalog No.: HY-168966
• CAS No.: 2097493-39-3
• Molecular Formula: C20H22F2N6O
• Molecular Weight: 400.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source