Yck2-IN-1

Overview

Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC 50 of approximately 80 nM against Yck2 and a MIC 80 of 12.5 µM against C. albicans , with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Casein Kinase

Product Information

• Catalog No.: HY-168998
• CAS No.: 401816-26-0
• Molecular Formula: C19H11FN4
• Molecular Weight: 314.32
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source