AFN-1252

Overview

AFN-1252 is an orally active and selective inhibitor of FabI , an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC 90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus . AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Antibiotic

Product Information

• Catalog No.: HY-16911
• CAS No.: 620175-39-5
• Molecular Formula: C22H21N3O3
• Molecular Weight: 375.42
• Purity: 99.49%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source