GDCNF-11

Overview

GDCNF-11 is a type of HSP90 interaction-mediated protein degradation chimera (HIM- PROTAC ) degrader that targets and degrades GPX4 , with a DC 50 of 0.08 μM. GDCNF-11 mediates the ubiquitination and proteasome-dependent degradation of GPX4 by recruiting GPX4 to form a ternary complex with HSP90 , increases intracellular lipid peroxides and ROS , and ultimately triggers Ferroptosis . GDCNF-11 inhibits tumor growth in mouse models, downregulates GPX4 protein in xenograft tumors, and upregulates the lipid peroxidation marker. GDCNF-11 can be used for the research of fibrosarcoma. (Pink: GPX4 ligand ( HY-153748 ); Blue: HSP90 ligand ( HY-10212 ); Black: linker ( HY-159772 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-169133
• CAS No.: 2991588-80-6
• Molecular Formula: C48H53Cl2N13O5S
• Molecular Weight: 994.99
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source