RPR-260243

Overview

RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG) , slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC 50 =58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel. RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-16915
• CAS No.: 668463-35-2
• Molecular Formula: C28H25F3N2O4
• Molecular Weight: 510.50
• Purity: 98.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (1.96 mM); Clear solution
• Availability: In-stock

Source

Original product source