JNK-1-IN-4

Overview

JNK-1-IN-4 (Compound E1) is an inhibitor for JNK , that inhibits JNK-1, JNK-2 and JNK-3 with IC 50 s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun , and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin ( HY-17565 )-induced mice idiopathic pulmonary fibrosis models.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-169177
• CAS No.: 3047795-60-5
• Molecular Formula: C22H25BrN6O3
• Molecular Weight: 501.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source