AK-1690

Overview

AK-1690 is a selective PROTAC degrader targeting STAT6 ( DC 50 =1 nM) with a K i of 6 nM against human STAT6 . AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc.. (Pink: STAT6 ligand ( HY-169182 ); Blue: Cereblon ligand ( HY-131318 ); Black: linker ( HY-W459522 )).

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Hodgkin Lymphoma | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-169179
• CAS No.: 2984505-88-4
• Molecular Formula: C51H56F2N5O11PS
• Molecular Weight: 1016.05
• Purity: 99.17%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.46 mM); Clear solution
• Availability: In-stock

Source

Original product source