PROTAC SMARCA2 degrader-21

Overview

PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA , that degrades SMARCA2 with a DC 50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC 50 of <1 nM and >100 nM, respectively. (Pink: SMARCA2 ligand ( HY-44824 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-169489 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-169272
• CAS No.: 2891464-61-0
• Molecular Formula: C54H66N12O5S
• Molecular Weight: 995.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source