JH-II-127

Overview

JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC 50 s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T . JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinson's syndrome.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > LRRK2

Product Information

• Catalog No.: HY-16936
• CAS No.: 1700693-08-8
• Molecular Formula: C19H21ClN6O3
• Molecular Weight: 416.86
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.75 mg/mL (6.60 mM); Clear solution
• Availability: In-stock

Source

Original product source