AGU654

Overview

AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC 50 of 2.9 nM against mPGES-1 . AGU654 inhibits mPGES-1 to block the pathway converting arachidonic acid into prostaglandin E2 ( PGE2 ) by COX-1/2 , thereby alleviating inflammatory responses, pain, and fever. In activated human monocyte-derived macrophages and human whole blood models, AGU654 selectively suppresses bacterial exotoxin-induced PGE2 production while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, exhibiting excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a strategy for studying inflammatory diseases and pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PGE synthase

Product Information

• Catalog No.: HY-169430
• CAS No.: 3038861-74-1
• Molecular Formula: C27H19ClF6N4O2
• Molecular Weight: 580.91
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source