(S)-AMG-628

Overview

(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 ( HY-123374 ). (S)-AMG-628 is the orally active antagonist for TRPV1 , that inhibits the Capsaicin ( HY-10448 )- and acid-induced Ca 2+ -influx with IC 50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin -induced rats flinching, and reverses the thermal hypersensitivity in CFA-( HY-153808 ) induced inflammatory pain models.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-169780
• CAS No.: 862269-92-9
• Molecular Formula: C25H25FN6O2S
• Molecular Weight: 492.57
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source