HUP-55

Overview

HUP-55 is a prolyl endopeptidase inhibitor ( IC 50 = 5 nM). HUP-55 reduces the dimerization of α-synuclein in Neuro2a cells and induces autophagy ( Autophagy ) in HEK293 cells. It also decreases the increase in reactive oxygen species ( ROS ) production induced by hydrogen peroxide in SH-SY5Y cells at a concentration of 10 μM. In a mouse Parkinson’s disease model, HUP-55 (10 mg/kg) improves motor function (reduces the use frequency of the impaired paw) and decreases the levels of harmful oligomers of α-synuclein in the striatum caused by overexpression of α-synuclein .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > α-synuclein

Product Information

• Catalog No.: HY-169831
• CAS No.: 3006795-68-9
• Molecular Formula: C18H21N3O
• Molecular Weight: 295.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source