W-54011

Overview

W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125 I-labeled C5a to human neutrophils with a K i value of 2.2 nM. W-54011 also inhibits C5a -induced intracellular Ca 2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC 50 s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Complement System | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-16992A
• CAS No.: 405098-33-1
• Molecular Formula: C30H37ClN2O2
• Molecular Weight: 493.08
• Purity: 98.0%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution
• Availability: In-stock

Source

Original product source