NP3-253

Overview

NP3-253 is an orally active and brain-penetranted NLRP3 inflammasome inhibitor. NP3-253 functions as a molecular glue that prevents NACHT-subdomain rearrangements, locking NLRP3 in an inactive conformation. NP3-253 inhibits production of pro-inflammatory cytokines IL-1β and IL-18 . NP3-253 can be used for the research of inflammation and neurological disease , suah as peritonitis.

Application

Products | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Peritonitis | Products > Disease Areas > Nonalcoholic Steatohepatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-169996
• CAS No.: 2557349-50-3
• Molecular Formula: C19H23F3N4O
• Molecular Weight: 380.41
• Purity: 99.78%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 5 mg/mL (13.14 mM); Clear solution
• Availability: In-stock

Source

Original product source