nNOS-IN-5 (Compound 9) is a potent human neuronal NOS ( nNOS ) inhibitor ( K i = 22 nM). nNOS-IN-5 exhibits excellent selectivity, with a 900-fold preference for human nNOS over human endothelial NOS ( eNOS ). nNOS-IN-5 can be used for neurodegenerative diseases study, such as Alzheimer's disease and Parkinson’s disease.
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